OBJECTIVES The student should be made to:
Learn characteristics and classification of Biomaterials
Understand different metals, ceramics and its nanomaterial‘s characteristics as biomaterials
Learn polymeric materials and its combinations that could be used as a tissue replacement implants
Get familiarized with the concepts of Nano Science and Technology
Understand the concept of biocompatibility and the methods for biomaterials testing
UNIT I INTRODUCTION TO BIO-MATERIALS 9
Definition and classification of bio-materials, mechanical properties, visco elasticity, biomaterial performance, body response to implants, wound healing, blood compatibility, Nano scale phenomena.
UNIT II METALLIC AND CERAMIC MATERIALS 9
Metallic implants – Stainless steels, co-based alloys, Ti-based alloys, shape memory alloy, nanostructured metallic implants, degradation and corrosion, ceramic implant – bio inert, biodegradable or bioresorbable, bioactive ceramics, nanostructured bio ceramics.
UNIT III POLYMERIC IMPLANT MATERIALS 9
Polymerization, factors influencing the properties of polymers, polymers as biomaterials, biodegradable polymers, Bio polymers: Collagen, Elastin and chitin. Medical Textiles, Materials for ophthalmology: contact lens, intraocular lens. Membranes for plasma separation and Blood oxygenation, electro spinning: a new approach.
UNIT IV TISSUE REPLACEMENT IMPLANTS 9
Small intestinal sub mucosa and other decullarized matrix biomaterials for tissue repair: Extra cellular Matrix. Softtissue replacements, sutures, surgical tapes, adhesive, Percutaneous and skin implants, maxillofacial augmentation, Vascular grafts, hard tissue replacement Implants, joint replacements, tissue scaffolding and engineering using Nano biomaterials.
UNIT V TESTING OF BIOMATERIALS: 9
Biocompatibility, blood compatibility and tissue compatibility tests, Toxicity tests, sensitization, carcinogenicity, mutagenicity and special tests, Invitro and Invivo testing; Sterilisation of implants and devices: ETO, gamma radiation, autoclaving. Effects of sterilization.
TOTAL: 45 PERIODS
OUTCOMES: At the end of the course, the student should be able to:
Analyze different types of Biomaterials and its classification and apply the concept of nanotechnology towards biomaterials use.
Identify significant gap required to overcome challenges and further development in metallic and ceramic materials
Identify significant gap required to overcome challenges and further development in polymeric materials
Create combinations of materials that could be used as a tissue replacement implant.
Understand the testing standards applied for biomaterials.
- Sujata V. Bhatt, ―Biomaterials‖, Second Edition, Narosa Publishing House, 2005.
- Sreeram Ramakrishna, MuruganRamalingam, T. S. Sampath Kumar, and Winston O. Soboyejo, ―Biomaterials: A Nano Approach‖, CRC Press, 2010.
- Myer Kutz, ―Standard Handbook of Biomedical Engineering & Design‖, McGraw Hill, 2003
- John Enderle, Joseph D. Bronzino, Susan M.Blanchard, ―Introduction to Biomedical Engineering‖, Elsevier, 2005.
- Park J.B., ―Biomaterials Science and Engineering‖, Plenum Press, 1984.
- A.C Anand, J F Kennedy, M.Miraftab, S.Rajendran,―Woodhead Medical Textiles and Biomaterials for Healthcare‖, Publishing Limited 2006.
- D F Williams, ―Materials Science and Technology: Volume 14, Medical and Dental Materials: A comprehensive Treatment Volume‖, VCH Publishers 1992.
- Monika Saini, Yashpal Singh, Pooja Arora, Vipin Arora, and KratiJain. ―Implant biomaterials: A comprehensive review‖, World Journal of Clinical Cases, 2015.